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Hexokinase
HEXOKINASE
- Catalyzes phosphorylation of glucose to form glucose-6P
- Traps glucose inside the cell
- 1st regulated enzymes in glycolysis – catalyze an irreversible reaction
- 4 isozymes – I, II, III, and IV (glucokinase)
- Ubiquitous in mammals
- Low Km & low Vmax
- Allosteric regulation – inhibited by glucose-6P