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Hexokinase

HEXOKINASE
  • Catalyzes phosphorylation of glucose to form glucose-6P
  • Traps glucose inside the cell
  • 1st regulated enzymes in glycolysis – catalyze an irreversible reaction
  • 4 isozymes – I, II, III, and IV (glucokinase)
  • Ubiquitous in mammals
  • Low Km & low Vmax
  • Allosteric regulation – inhibited by glucose-6P