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Glucokinase

Glucokinase
  • Liver & pancreatic beta cells
  • High Km & high Vmax: spares glucose for brain, muscle & other tissues (glucose sensor)
  • Hormonal regulation: inhibited by glucagon, activated by insulin
  • Glucokinase regulatory protein (GKRP): nuclear protein that reversibly binds/inactivates glucokinase
  • High [glucose] inhibits GKRP & promotes glucokinase release
  • Fructose-6P (glycolytic intermediate in equilibrium with glucose-6P): promotes GKRP-GK binding
  • Liver glucose-6P shunts into one of three pathways: glycolysis, glycogen or fatty acid synthesis

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