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Amino Acids: Hydrophobic/Aliphatic
    * Let's start with alanine, also written as Ala or A.
  • Draw a general amino acid stick structure and replace the R with a line.
    • Remind ourselves: what does the line represent? A methyl (CH3) group.
    • Alanine is considered to be the simplest amino acid (even though glycine has a simpler R group) because its R group is large enough to give it some steric constraints, but small enough to prevent major changes in protein structure.
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Amino Acids: Hydrophobic/Aliphatic

Hydrophobic
Alanine (Ala, A)
Valine (Val, V)
  • Beta branching; branch at the beta carbon
Leucine (Leu, L)
  • Branch on gamma carbon
Isoleucine (Ile, I)
  • Beta branching
  • Isomer of leucine (same formula, different arrangement of atoms)
Methionine (Met, M)
  • Contains sulfur atom