Fates of Pyruvate - 2. Gluconeogenesis
KEY FATES OF PYRUVATE
1. Acetyl CoA: substrate for citric acid cycle and fatty acid synthesis
2. Oxaloacetate: intermediate in CAC and substrate for gluconeogenesis
3. Lactate: produced by eukaryotes in absence of oxygen
4. Ethanol: produced by yeast and some bacteria (including intestinal flora) in absence of oxygen.
- There are aerobic and anaerobic conditions.
Gluconeogenesis: Pyruvate converts to oxaloacetate
- Aerobic conditions
- Fasting conditions (glucose in demand)
- Occurs in liver (minor process in kidneys): mitochondrial matrix
- Pyruvate carboxylase
- Irreversible reaction
- Oxaloacetate is substrate for gluconeogenesis and CAC intermediate